In Act 3 of Baldur's Gate 3, one of the two main quests is to locate and enter the Temple of Bhaal. Even if players fully cooperate with Orin the Red, they still need to find a way into her sanctum to present her with Gortash's head.
Baldur's Gate 3: How to Enter the Temple of Bhaal (Rescue Orin's Victim)
With the Amulet of Bhaal in hand, players must venture into the Undercity to find the god of murder's temple.