It takes about 15 hours to beat the main story in Marvel's Spider-Man 2. Marvel's Spider-Man 2 is technically the third entry in Insomniac's Spider-Man series, serving as a direct sequel to both the 2018 Spider-Man game and 2020's Spider-Man: Miles Morales.
Spider-Man 2: How Long to Beat and Get the Platinum Trophy
Here's about how long it will take most people to beat Marvel's Spider-Man 2's main story and unlock the Platinum trophy.