At a certain point in the story, players will get an opportunity to try out a Mysterium, a new gadget created by Mysterio to provide entertainment for people. However, it turns out that it has many problems. So, it is up to the players to fix the Mysteriums and save the people trapped inside.
Spider-Man 2: All Mysterium Locations
By completing all the Mysteriums, Marvel's Spider-Man 2 players will unlock a new suit for Miles.