Spoilers for Marvel's Spider-Man, but Aunt May, Peter Parker's caregiver, passes away due to being inflicted by Doctor Octopus' Devil's Breath. And years before the events of the first Insomniac Spider-Man game, Peter's uncle Ben got murdered. This takes us to Spider-Man 2, where Peter is without a close parental-like relationship, leaning on his girlfriend M.J., Miles Morales, and Harry for support.